Selected Publications
SYED
1. Heba Ewida, Harrison Benson, Syed Tareq, and Mahmoud Salama Ahmed. Molecular Targets and Small
Molecules Modulating Acetyl Coenzyme A in Physiology and Diseases. ACS Pharmacology & Translational
Science, 8, 36-46, 2025.
2. Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen, Yuji Nakada, Ching-Cheng Hsu, Ayman Farag, Nicholas T
Lam, Ping Wang, Suwannee Thet, Ivan Menendez-Montes, Waleed M Elhelaly, Xi Lou, Ilaria Secco, Mateusz
Tomczyk, Lorena Zentilin, Jimin Pei, Miao Cui, Matthieu Dos Santos, Xiaoye Liu, Yan Liu, David Zaha, Gregory
Walcott, Diana R Tomchick, Chao Xing, Cheng Cheng Zhang, Nick V Grishin, Mauro Giacca, Jianyi Zhang,
Hesham A Sadek “Identification of FDA-Approved Drugs That Induce Heart Regeneration in Mammals” Nat
Cardiovasc Res. 3, 372–388, 2024.
3. Mahmoud Salama Ahmed, Ping wang, Yuji Nakada, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Mark Henkemeyer, Enas Kandil, Hesham Sadek “Identification of tetracycline combinations as EphB tyrosine kinase inhibitors for treatment of neuropathic pain” Proceedings National Academy of Sciences, USA, 118 (10) e2016265118, 2021. Highlighted at the cover, March 2021 issue.
List of Publications
2026
Ivan Menendez-Montes, Consuelo Marin-Vicente, Shibani Mukherjee, Mahmoud Salama Ahmed, Manuel Jose Gomez, Chukwuemeka George Anene-Nzelu, Chang Jie Mick Lee, Svenja Koslowski, Ashley Solmonson, Tara Tassin, Shah R Ali, Pedro Pessoa, Abdallah Elnwasany, Nicholas T Lam, Suwannee Thet, Enrique Calvo, Alisson C Cardoso, Ana Helena M Pereira, Feng Xiao, Ping Wang, Asim Mohamed, Hamed El-Feky, Ahmed Elghamry, Gonzalo Gancedo-Alonso, Ngoc Uyen Nhi Nguyen, Ching-Cheng Hsu, Aundrea K Westfall, Ralph DeBerardinis, Roger Sik-Yin Foo, Michael Kinter, Steve Pressé, Chao Xing, Luke Szweda, Asaithamby Aroumougame, Fatima Sanchez-Cabo, Jose Antonio Enriquez, Miguel Torres, Jesus Vazquez, Hesham A Sadek. “Mitochondria directly interact with the nuclear pore complex” Nature, 654, 786-797, 2026.
Harrison Benson, Komalpreet Kaur, Mahmoud Salama Ahmed “Targeting druggable kinases in neuropathic pain” NPJ Drug Discovery, 3, 22, 2026.
Justin Hierholzer, Harrison Benson, Heba A Ewida, Mahmoud Salama Ahmed “Mitigating loss of lean muscle in GLP-1 and dual GLP-1/GIP agonists: Pipeline opportunities and limitations” Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1872, 4, 168172, 2026.
2025
Heba A Ewida, Md Tareq Aziz, Syed Tareq, Prasanth K Chelikani, Mahmoud Salama Ahmed. “Pan-EphB tyrosine kinase inhibitor mitigates diabetic cardiomyopathy” BioRxiv. doi: https://doi.org/10.1101/2025.11.17.688935.
Syed Tareq, Heba A. Ewida, Sumaih Zoubi et al., Mahmoud Salama Ahmed “Discovery of pan-EphB tyrosine kinase inhibitor for metabolic syndrome sparing EphB3 signaling in mice” Pharmacological Research, 219, 107900, 2025.
Nicholas T Lam, Ngoc Uyen Nhi Nguyen, Waleed M Elhelaly, Ching-Cheng Hsu, Ivan Menendez-Montes, Feng Xiao, Shah R Ali, Nelson Vo, Nathan Briard, Lobna El-Feky, Qamar M Omari, Alisson C Cardoso, Yan Liu, Mahmoud Salama Ahmed, Shujuan Li, Suwannee Thet, Chao Xing, Lior Zangi, Hesham A Sadek “Induced Cytokinesis Generates Highly Proliferative Mononuclear Cardiomyocytes at the Expense of Contractility” Circulation, 151, 1009, 2025.
Ping Wang, Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen et al., “An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models” The Journal of Clinical Investigation, 135, 14, 2025.
Shereen A El Sobky, Injie O Fawzy, Mahmoud Salama Ahmed, Manon Ragheb, Merna HM Hamad, Rowan Bahaaeldin, Salma A Fahim, Rana Saad, Ziad A Khalil, Sara H Mahmoud, Ahmed Mostafa, Mohamed A Ali, Hesham A Sadek, Nada El-Ekiaby, Ahmed I Abdelaziz “Drug repurposing of argatroban, glimepiride and ranolazine shows anti-SARS-CoV-2 activity via diverse mechanisms” Heliyon, 11, 3, 2025.
Heba Ewida, Harrison Benson, Syed Tareq, and Mahmoud Salama Ahmed “Molecular Targets and Small Molecules Modulating Acetyl Coenzyme A in Physiology and Diseases” ACS Pharmacology & Translational Science, 8, 36-46, 2025.
2024
Ghada ME Ali, Menna A Ewida, Amira M Elmetwali, Heba A Ewida, Riham F George, Walaa R Mahmoud, Nasser SM Ismail, Mahmoud Salama Ahmed, Hanan H Georgey “Discovery of pyrazole-based analogs as CDK2 inhibitors with apoptotic-inducing activity: design, synthesis and molecular dynamics study” RSC Advances, 14, 34537-34555, 2024.
Hebatollah Ewida et al., Mahmoud Salama Ahmed "Structure-Based Drug Repurposing Targeting Malonyl CoA Decarboxylase for Treatment of Obesity" JPET, 389 (S3) 282, June 2024.
Mahmoud Salama Ahmed, Ngoc Uyen Nhi Nguyen et al., “Identification of FDA-Approved Drugs That Induce Heart Regeneration in Mammals” Nat Cardiovasc Res. 3, 372–388, 2024.
2023
Mahmoud Salama Ahmed et al., “FDA approved drugs with antiviral activity against SARS-CoV-2: From structure-based repurposing to host-specific mechanisms” Biomedicine & Pharmacotherapy, 162, 114614, 2023.
2022
Nicholas T. Lam, Ngoc Uyen Nhi Nguyen, Mahmoud Salama Ahmed, Ching-Cheng Hsu, Pamela E. Rios Coronado, Shujuan Li, Ivan Menendez-Montes, Suwannee Thet, Waleed M. Elhelaly, Feng Xiao, Xiaoyu Wang, Noelle S. Williams, Diana C. Canseco, Kristy Red-Horse, Beverly A. Rothermel, Hesham A. Sadek “Targeting calcineurin induces cardiomyocyte proliferation in adult mice” Nat Cardiovasc Res. 2022.
Jain MK, De Lemos JA, McGuire DK, Ayers C, Eitson JL, Sanchez CL, Kamel D, Meisner JA, Thomas EV, Hegde AA, Mocherla S, Strebe JK, Li X, Williams NS, Xing C, Ahmed MS, Wang P, Sadek HA, Schoggins JW. Atovaquone for treatment of COVID-19: A prospective randomized, double-blind, placebo-controlled clinical trial. Front Pharmacol. 2022 Sep 30;13:1020123
Galal MW, Ahmed MS, Shao Y, Xing C, Ali W, Baly AE, Elfiky A, Amer K, Schoggins J, Sadek HA, Gobara ZN. The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study. Advances in Virology. 2022;2022:3014686.
2021
Mahmoud Salama Ahmed, Ping wang, Yuji Nakada, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Mark Henkemeyer, Enas Kandil, Hesham Sadek “Identification of tetracycline combinations as EphB tyrosine kinase inhibitors for treatment of neuropathic pain” PNAS, 118 (10) e2016265118, 2021. Highlighted at the cover, March 2021 issue.
Menna Ewida, Heba Ewida, Mahmoud Salama Ahmed, Heba Abdel-Rasheed Allam, Ramzia ElBagary, Riham George, Hanan Georgey, Hussein El-Subbagh “Nanomolar potency of imidazo[2,1-b]thiazole analogs as indoleamine 2,3 dioxygenase inhibitors” Arch. Pharm. 2021; e2100202.
Menna A. Ewida, Heba A. Ewida, Mahmoud Salama Ahmed, Heba Abdel-Rasheed Allam, Ramzia I. ElBagary, Riham F. George, Hanan H. Georgey, Hussein I. El-Subbagh “3-Methyl-imidazo[2,1-b] thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations" Bioorganic Chemistry, 115, 105205, 2021.
Dina M. El-Kersh, Shahira M. Ezzat, Maha M. Salama, Engy A. Mahrous, Yasmeen M. Attia, Mahmoud Salama Ahmed, Mohey M. Elmazar “Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer” Scientific Reports, 11, 7121, 2021.
2020
Mahmoud Salama Ahmed, Hesham Sadek “Hypoxia induces cardiomyocyte proliferation in humans” JACC: Basic to Translational Science 5 (5), 461, 2020.
Ngoc Uyen Nhi Nguyen, Diana C. Canseco, Feng Xiao, Yuji Nakada, Shujuan Li, Nicholas T. Lam, Shalini A. Muralidhar, Jainy J. Savla, Joseph A. Hill, Victor Le, Zhaoning Wang, Mahmoud Salama Ahmed, Maimon E. Hubbi, Ivan Menendez-Montes, Jesung Moon, Shah R. Ali, Victoria Le, Elisa Villalobos, Magid S. Mohamed, Waleed M. Elhelaly, Suwannee Thet, Chukwuemeka George Anene-Nzelu, Wilson Lek Wen Tan, Roger S. Foo, Xun Meng, Mohammed Kanchwala, Chao Xing, Jagoree Roy, Martha S. Cyert, Beverly A. Rothermel, Hesham A. Sadek “A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes” Nature, 582, 271-276, 2020.
Alisson C Cardoso, Nicholas T Lam, Jainy J Savla, Yuji Nakada, Ana Helena M Pereira, Abdallah Elnwasany, Ivan Menendez-Montes, Emily L Ensley, Ursa Bezan Petric, Gaurav Sharma, A Dean Sherry, Craig R Malloy, Chalermchai Khemtong, Michael T Kinter, Wilson Lek Wen Tan, Chukwuemeka G Anene-Nzelu, Roger SikYin Foo, Ngoc Uyen Nhi Nguyen, Shujuan Li, Mahmoud Salama Ahmed, Waleed M Elhelaly, Salim Abdisalaam, Aroumougame Asaithamby, Chao Xing, Mohammed Kanchwala, Gonçalo Vale, Kaitlyn M Eckert, Matthew A Mitsche, Jeffrey G McDonald, Joseph Hill, Linzhang Huang, Philip Shaul, Luke I Szweda, Hesham Sadek “Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression” Nature Metabolism, 2, 167-178, 2020.
Samy Mohamady, Abdullah Ahmed Gibriel, Mahmoud Salama Ahmed, Moataz S Hendy, Bassem H Naguib “Design and novel synthetic approach supported with molecular docking and biological evidence for naphthoquinone-hydrazinotriazolothiadiazine analogs as potential anticancer inhibiting topoisomerase-IIB” Bioorganic Chemistry 96, 10364, 2020.
2019
Mater Mahnashi, Sara Elgazwi, Mahmoud Salama Ahmed, Fathi Halaweish “Cucurbitacins inspired organic synthesis: Potential dual inhibitors targeting EGFR – MAPK pathway” European Journal of medicinal chemistry, 173, 294-304, 2019.
Moataz Hendy, Aya Ali, Lubna Ahmed, Reham Hossam, Alaa Mostafa, Mohamed Elmazar, Bassem Naguib, Yasmeen Attia, Mahmoud Salama Ahmed “Structure-based drug design, synthesis, In vitro, and In vivo biological evaluation of indole-based biomimetic analogs targeting estrogen receptor-α inhibition” European Journal of medicinal chemistry, 166, 281-290, 2019.
2018
Ayman Farag, Heba Ewida, Mahmoud Salama Ahmed “Design, Synthesis, and Biological evaluation of novel amide and hydrazide-based analogs targeting Histone Deacetylase (HDACs)” European Journal of medicinal chemistry, 148, 73 -85, 2018.
Bassam Ayoub, Yasmeen Attia, Mahmoud Salama Ahmed “Structural repositioning, in-silico molecular modeling, oxidative degradation, and screening of linagliptin as adenosine 3 receptor (ADORA3) modulators targeting hepatocellular carcinoma” Journal of enzyme inhibition and medicinal chemistry, 33, 858 - 866, 2018.
Abdulrhman Alsayari, Lucas Kopel, Mahmoud Salama Ahmed, Hesham Soliman, Sivakumar Annadurai, Fathi Halaweish “Isolation of anticancer constituents from Cucumis proph. var. prophetarum through bioassay-guided fractionation” BMC complementary and alternative medicine, 18, 274-, 2018.
Rania Ismail, Sahar Abou-Seri, Wagdy Eldehna, Nasser Ismail, Sara Elgazwi, Hazem Ghabbour, Mahmoud Salama Ahmed, Fathi Halaweish, Dalal Abou El Ella “Novel series of 6-(2-substitutedacetamido)-4- anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells” European Journal of medicinal chemistry, 155, 782-796, 2018.
2017
Hajer Arjaibi, Mahmoud Salama Ahmed, Fathi Halaweish “Mechanistic investigation of hepatoprotective potential for cucurbitacins” Medicinal chemistry research, 26, 1567-1573, 2017.
Abdulrhman Alsayari, Lucas Kopel, Mahmoud Salama Ahmed, Adam Pay, Taylor Carlson, Fathi Halaweish “Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents” Steroids, 118, 32-40, 2017.
Mahmoud Salama Ahmed, Fardous El-Senduny, Jessica Taylor, and Fathi Halaweish “Biological screening of cucurbitacin inspired estrone analogs targeting mitogen activated protein kinase (MAPK) pathway” Chemical Biology and Drug Design, 90, 478-484, 2017.
2014
Mahmoud Salama Ahmed, Lucas Kopel, Fathi Halaweish “Structural optimization and biological screening of a steroidal scaffold possessing cucurbitacin-like functionalities as BRAF Inhibitors” ChemMedChem, 9, 7, 1361–1367, 2014.
Mahmoud Salama Ahmed and Fathi T. Halaweish “Cucurbitacins: Potential candidates targeting mitogen activated protein kinase pathway for treatment of melanoma” Journal of enzyme inhibition and medicinal chemistry, 29, 162-167, 2014.
2013
Lucas Kopel, Mahmoud Salama Ahmed, Fathi Halaweish “Synthesis of estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain” Steroids, 78, 13, 1119-1125, 2013.
2012
Mukulesh Baruah, Eric Huntimer, Mahmoud Salama Ahmed, Adam Hoppe, Fathi Halaweish “Selective BODIPY ® based fluorescent chemosensor imaging Pb2+ ion in living cells” Tetrahedron letters, 53, 33, 4253-4476, 2012.
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