Selected Publications
1. Mahmoud Salama Ahmed, Ping wang, Yuji Nakada, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Mark Henkemeyer, Enas Kandil, Hesham Sadek “Identification of tetracycline combinations as EphB tyrosine kinase inhibitors for treatment of neuropathic pain” Proceedings National Academy of Sciences, USA, 118 (10) e2016265118, 2021. Highlighted at the cover, March 2021 issue.
2. Moataz Hendy, Aya Ali, Lubna Ahmed, Reham Hossam, Alaa Mostafa, Mohamed Elmazar, Bassem Naguib, Yasmeen Attia, Mahmoud Salama Ahmed “Structure-based drug design, synthesis, In vitro, and In vivo biological evaluation of indole-based biomimetic analogs targeting estrogen receptor-α inhibition” European Journal of medicinal chemistry, 166, 281-290, 2019. Role: Corresponding author.
3. Ayman Farag, Heba Ewida, Mahmoud Salama Ahmed “Design, Synthesis, and Biological evaluation of novel amide and hydrazide-based analogs targeting Histone Deacetylase (HDACs)” European Journal of medicinal chemistry, 148, 73 -85, 2018. Role: Corresponding author.
List of Publications
Nicholas T. Lam, Ngoc Uyen Nhi Nguyen, Mahmoud Salama Ahmed, Ching-Cheng Hsu, Pamela E. Rios Coronado, Shujuan Li, Ivan Menendez-Montes, Suwannee Thet, Waleed M. Elhelaly, Feng Xiao, Xiaoyu Wang, Noelle S. Williams, Diana C. Canseco, Kristy Red-Horse, Beverly A. Rothermel, Hesham A. Sadek “Targeting calcineurin induces cardiomyocyte proliferation in adult mice” Nat Cardiovasc Res. 1, 679–688 2022.
Jain MK, De Lemos JA, McGuire DK, Ayers C, Eitson JL, Sanchez CL, Kamel D, Meisner JA, Thomas EV, Hegde AA, Mocherla S, Strebe JK, Li X, Williams NS, Xing C, Ahmed MS, Wang P, Sadek HA, Schoggins JW. Atovaquone for treatment of COVID-19: A prospective randomized, double-blind, placebo-controlled clinical trial. Front Pharmacol. 2022 Sep 30;13:1020123
Galal MW, Ahmed MS, Shao Y, Xing C, Ali W, Baly AE, Elfiky A, Amer K, Schoggins J, Sadek HA, Gobara ZN. The Use of Mebendazole in COVID-19 Patients: An Observational Retrospective Single Center Study. Advances in Virology. 2022;2022:3014686.
Mahmoud Salama Ahmed, Ping wang, Yuji Nakada, Ivan Menendez-Montes, Ngoc Uyen Nhi Nguyen, Mark Henkemeyer, Enas Kandil, Hesham Sadek “Identification of tetracycline combinations as EphB tyrosine kinase inhibitors for treatment of neuropathic pain” Proceedings National Academy of Sciences, USA, 118 (10) e2016265118, 2021. Highlighted at the cover, March 2021 issue.
Menna A. Ewida, Heba A. Ewida, Mahmoud Salama Ahmed, Heba Abdelrasheed Allam, Ramzia I. ElBagary, Riham F. George, Hanan H. Georgey, Hussein I. El-Subbagh “Nanomolar potency of imidazo[2,1-b]t hiazole analogs as indoleamine 2,3 dioxygenase inhibitors” Arch. Pharm. 2021; e2100202.
Menna A. Ewida, Heba A. Ewida, Mahmoud Salama Ahmed, Heba Abdelrasheed Allam, Ramzia I. ElBagary, Riham F. George, Hanan H. Georgey, Hussein I. El-Subbagh “3-Methyl-imidazo[2,1-b] thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations" Bioorganic Chemistry, 115, 105205, 2021.
Dina M. El-Kersh, Shahira M. Ezzat, Maha M. Salama, Engy A. Mahrous, Yasmeen M. Attia, Mahmoud Salama Ahmed, Mohey M. Elmazar “Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer” Scientific Reports, 11, 7121, 2021.
Mahmoud Salama Ahmed, Hesham Sadek “Hypoxia induces cardiomyocyte proliferation in humans” JACC: Basic to Translational Science 5 (5), 461, 2020.
Ngoc Uyen Nhi Nguyen, Diana C. Canseco, Feng Xiao, Yuji Nakada, Shujuan Li, Nicholas T. Lam, Shalini A. Muralidhar, Jainy J. Savla, Joseph A. Hill, Victor Le, Zhaoning Wang, Mahmoud Salama Ahmed, Maimon E. Hubbi, Ivan Menendez-Montes, Jesung Moon, Shah R. Ali, Victoria Le, Elisa Villalobos, Magid S. Mohamed, Waleed M. Elhelaly, Suwannee Thet, Chukwuemeka George Anene-Nzelu, Wilson Lek Wen Tan, Roger S. Foo, Xun Meng, Mohammed Kanchwala, Chao Xing, Jagoree Roy, Martha S. Cyert, Beverly A. Rothermel, Hesham A. Sadek “A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytes” Nature, 582, 271-276, 2020.
Alisson C Cardoso, Nicholas T Lam, Jainy J Savla, Yuji Nakada, Ana Helena M Pereira, Abdallah Elnwasany, Ivan Menendez-Montes, Emily L Ensley, Ursa Bezan Petric, Gaurav Sharma, A Dean Sherry, Craig R Malloy, Chalermchai Khemtong, Michael T Kinter, Wilson Lek Wen Tan, Chukwuemeka G Anene-Nzelu, Roger Sik-Yin Foo, Ngoc Uyen Nhi Nguyen, Shujuan Li, Mahmoud Salama Ahmed, Waleed M Elhelaly, Salim Abdisalaam, Aroumougame Asaithamby, Chao Xing, Mohammed Kanchwala, Gonçalo Vale, Kaitlyn M Eckert, Matthew A Mitsche, Jeffrey G McDonald, Joseph A Hill, Linzhang Huang, Philip W Shaul, Luke I Szweda, Hesham A Sadek “Mitochondrial substrate utilization regulates cardiomyocyte cell-cycle progression” Nature Metabolism, 2, 167-178, 2020.
Samy Mohamady, Abdullah Ahmed Gibriel, Mahmoud Salama Ahmed, Moataz S Hendy, Bassem H Naguib “Design and novel synthetic approach supported with molecular docking and biological evidence for naphthoquinone-hydrazinotriazolothiadiazine analogs as potential anticancer inhibiting topoisomerase-IIB” Bioorganic Chemistry 96, 10364, 2020. (co-corresponding author)
Mater Mahnashi, Sara Elgazwi, Mahmoud Salama Ahmed, Fathi Halaweish “Cucurbitacins inspired organic synthesis: Potential dual inhibitors targeting EGFR – MAPK pathway” European Journal of medicinal chemistry, 173, 294-304, 2019. (co-corresponding author)
Moataz Hendy, Aya Ali, Lubna Ahmed, Reham Hossam, Alaa Mostafa, Mohamed Elmazar, Bassem Naguib, Yasmeen Attia, Mahmoud Salama Ahmed “Structure-based drug design, synthesis, In vitro, and In vivo biological evaluation of indole-based biomimetic analogs targeting estrogen receptor-α inhibition” European Journal of medicinal chemistry, 166, 281-290, 2019.
Ayman Farag, Heba Ewida, Mahmoud Salama Ahmed “Design, Synthesis, and Biological evaluation of novel amide and hydrazide-based analogs targeting Histone Deacetylase (HDACs)” European Journal of medicinal chemistry, 148, 73 -85, 2018.
Bassam Ayoub, Yasmeen Attia, Mahmoud Salama Ahmed “Structural repositioning, in-silico molecular modeling, oxidative degradation, and screening of linagliptin as adenosine 3 receptor (ADORA3) modulators targeting hepatocellular carcinoma” Journal of enzyme inhibition and medicinal chemistry, 33, 858 - 866, 2018.
Abdulrhman Alsayari, Lucas Kopel, Mahmoud Salama Ahmed, Hesham Soliman, Sivakumar Annadurai, Fathi Halaweish “Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation” BMC complementary and alternative medicine, 18, 274-, 2018.
Rania Ismail, Sahar Abou-Seri, Wagdy Eldehna, Nasser Ismail, Sara Elgazwi, Hazem Ghabbour, Mahmoud Salama Ahmed, Fathi Halaweish, Dalal Abou El Ella “Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells” European Journal of medicinal chemistry, 155, 782-796, 2018.
Hajer Arjaibi, Mahmoud Salama Ahmed, Fathi Halaweish “Mechanistic investigation of hepatoprotective potential for cucurbitacins” Medicinal chemistry research, 26, 1567-1573, 2017.
Abdulrhman Alsayari, Lucas Kopel, Mahmoud Salama Ahmed, Adam Pay, Taylor Carlson, Fathi Halaweish “Design, synthesis, and biological evaluation of steroidal analogs as estrogenic/anti-estrogenic agents” Steroids, 118, 32-40, 2017.
Mahmoud Salama Ahmed, Fardous El-Senduny, Jessica Taylor, and Fathi Halaweish “Biological screening of cucurbitacin inspired estrone analogs targeting mitogen activated protein kinase (MAPK) pathway” Chemical Biology and Drug Design, 90, 478-484, 2017.
Mahmoud Salama Ahmed, Lucas Kopel, Fathi Halaweish “Structural optimization and biological screening of a steroidal scaffold possessing cucurbitacin-like functionalities as BRAF Inhibitors” ChemMedChem, 9, 7, 1361–1367, 2014.
Mahmoud Salama Ahmed and Fathi T. Halaweish “Cucurbitacins: Potential candidates targeting mitogen activated protein kinase pathway for treatment of melanoma” Journal of enzyme inhibition and medicinal chemistry, 29, 162-167, 2014.
Lucas Kopel, Mahmoud Salama Ahmed, Fathi Halaweish “Synthesis of estrone analogs by incorporation of thiophenols via conjugate addition to an enone side chain” Steroids, 78, 13, 1119-1125, 2013.
Mukulesh Baruah, Eric Huntimer, Mahmoud Salama Ahmed, Adam Hoppe, Fathi Halaweish “Selective BODIPY ® based fluorescent chemosensor imaging Pb2+ ion in living cells” Tetrahedron letters, 53, 33, 4253-4476, 2012.
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